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"Grey's Anatomy" lost one of its surgeons on Thursday's sixth-season premiere, when Dr. George O'Malley died during the opening moments of the show.
The plot came as no surprise to fans who kept up with entertainment magazines over the summer. That's when viewers learned actor T.R. Knight, who portrays George O'Malley, wouldn't be returning to the show.
Two character's fates were uncertain when the last season of "Grey's" wrapped up. One of those characters was O'Malley, who jumped in front of a bus to rescue a woman he didn't know. The other character hanging to life: Dr. Izzie Stevens (Katherine Heigl), who had struggled with a brain tumor throughout the season.
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