Serotonin
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CBD does not bind to CB1 or CB2 receptors like THC does, but instead binds to a relatively unknown cannabinoid receptor GPR55 where it is an antagonist, as opposed to THC's partial agonism of the main CB receptors. 5-HT1A agonism has shown to inhibit glutamate and acetylcholine release in the cerebral cortex and hippocampus.
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Lol, is this voice recorded from google translate ???
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YO DUDE CALM DOWN ON THE SERO.....LOOK WHAT IT DID TO UR VOICE
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Wait how can cannabidiol antagonize THC? Do you mean it is a competitive agonist to cannabinoid receptors? I'm probably missing something. Do you know if 5-HT1A agonism increases glutamate activity in the cerebral cortex? I know 5-HT2 receptor agonism via indole psychedelics does, but I am not aware of similar properties of 5HT1A, but it would make sense seeing as THC inhibits cerebral interneurons allowing pyramidal neurons to fire.
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What do you mean obviously? Serotonin has nothing to do with the reward pathway. Tetrahydrocannabinol binds to CB1 and CB2 receptors, and also activates some μ1 Opioid pathways, which releases Dopamine.
Another constituent of the plant, Cannabidiol, which is an indirect antagonist of THC, is also an agonist of the 5-HT1A receptor, so it has partial serotonergic effects.
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@alenammetz - educated people all over the world know who he is.
DOPES WOULDN'T HAVE A CLUE WHO HE IS.
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@alenammetz lol
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Don't you people know who Stephen Hawking is?!
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maybe add subtitles?
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Stephen Hawking((((((((((((=
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voice fail
neurochris 1 year ago 48
wth is up with that voice :O
schoolbrat 2 years ago 16