LTP Mechanisms

The two main hypotheses to explain LTP are presynaptic, in which increased neurotransmitter is released; and postsynaptic, in which sensitivity to neurotransmitter is somehow increased. Video Reference: http://www.learner.org
From http://www.dnatube.com/video/217/LTP-Mechanisms

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Science & Technology

Tags:

• LTP
• Mechanisms

[j40505]

LTP is the basis for synaptic plasticity and ofcourse memory ( as is thought).

btw the video is quite poor in the explanation....

beause the predominant theory of LTP ( in pyramida cell for example,remeber the ltp mechanism may differ in different parts of the brain)

-high frequency stimulus eventuallly (after the cascade of reaction) releases calcium from post-synaptic membrane and this either

-increases sensitivity of AMPA recetors

-Increase no. of receptors to increase synpatic strength

[cmc335]

@j40505 more specifically, NMDA receptors require not only a ligand agonist to open, but also requires the binding of glycine. Together these open the NMDAR's "gate," which in turn causes an influx of Na and Ca, however NMDAR is still further blocked by a Mg ion within the receptor. The depolarization caused by the Na and Ca influx causes the Mg to exit the receptor, allowing Na and Ca into the cell. Increased Ca then facilitates the insertion of AMPA receptors. More AMPA = higher sensitivity.

[lbreakzl]

I thought that there are always much more neurotransmitters than receptors.