The Family of Genome Guardians: Tetramers of P73 and P53

The members of P53 family of transcription factors (P53, P63 and P73) function as oligomers in cell-cyle control and development. The structure of P73 and P53 tetramerization domains could be described as a dimer of dimers and the major difference between them is the presence of an additional C-terminal helix in P73 essential to stabilize the tetramer, allowing the formation of hetero-oligomers, in contrast to P53 which forms only homo-tetramer. This suggests the functional divergence and specification among the family members (2WQI.pdb; ref. Joerger et al. PNAS v106, 17705 and 1SAE.pdb; ref. Clore et al. Nat Str Bio v4, 253).

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