Warning on Avastin and Brain-Capillary Leaks

Genentech is alerting healthcare professionals about two new safety issues for Avastin or bevacizumab, a drug used to treat certain colorectal and lung cancers.

The first is a rare brain-capillary leak problem called reversible posterior
leukoencephalopathy syndrome (RPLS). RPLS is a neurological disorder associated with hypertension, fluid retention and the cytotoxic effects of immunosuppressive drugs on the vascular endothelium. The onset of symptoms can occur from 16 hours to 1 year after starting Avastin treatment. These symptoms can include headache, seizures, visual disturbances and altered mental function with or without hypertension.

An MRI is needed to establish a diagnosis of RPLS. The company says that if your patient develops RPLS, you should stop Avastin therapy and start treating the hypertension, if present. Symptoms of RPLS usually resolve or improve within days, although some patients continue to have ongoing neurological sequela. It is not known whether it is safe to restart Avastin therapy in patients who have already experienced RPLS.

The second safety issue concerns patients on Avastin who have experienced perforation of the nasal septum. Seven cases of this adverse event have been reported since the drug was marketed.

Category:

News & Politics

Tags:

• Avastin
• Brain-Capillary
• Leaks
• FDA
• Colorectal
• Lung
• Cancer
• Patient
• Safety
• RPLS
• Hypertension

[hotdream38ch]

The best way to prevent (or cure) cancer is have a good level of NATURAL vitamin D in our body. Natural vitamin D means that our body has to do it from the UV rays of the sun. There is no other way. All the rest is bullshit. And the sun if free (Avastin costs about $ 8000 per month and will destroy your body).

Natural vitamin D from UV rays will protect you from all cancer (including melanoma!), this is the truth, but the "cancer societies" get money from the Big Pharma to tell you lies.