Insulin Signaling (Signal Pathways)

NDSU Virtual Cell Animations Project animation 'Insulin Signaling'. For more information please see http://vcell.ndsu.edu/animations.

When high levels of glucose enter the blood stream, insulin is released by beta cells in the pancreas. Insulin then initiates a number of signal pathways in specific muscle and fat cells. This takes a look at the signal pathway responsible for allowing those cells to rapidly increase their ability to uptake glucose from the blood stream.

Category:

Education

Tags:

• signal
• pathway
• biology
• eukaryotic
• insulin
• glucose

[chewbaccaisnthuman]

even more amazing than the explanation it's the simple fact that this happens

[shawnchong89]

Here is some additional explanation if your studying this for an exam like me: starting at 2:00, the insulin binds to a insulin receptor that has 4 subunits 2 Alpha and 2 beta, the insulin binds to the alpha subunits in the extra cellular matrix that causes a conformational change in the 2 beta subunits, that results in the beta subunit becoming active kinase

[zackboomer]

@shawnchong89 tyrosine kinase then phosphorylates itself, and then tyrosine kinase transfers a phosphoryl group onto a target protein

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[shawnchong89]

Here is some additional explanation if your studying this for an exam like me: starting at 2:00, the insulin binds to a insulin receptor that has 4 subunits 2 Alpha and 2 beta, the insulin binds to the alpha subunits in the extra cellular matrix that causes a conformational change in the 2 beta subunits, that results in the beta subunit becoming active kinase

[TheKatKatPower]

simply amazing!! i love your videos!!!

[OpheliaCat8]

great animation, but I had a hard time following the pathway so I could understand it. The pretty animation was more distracting than helpful.

[MegaMyristica]

thank you

[pickinvidders]

The video seems to show, in fat cells, three glucoses being converted to glycerol to provide the backbone of a single triacyglycerol molecule. Actually glycerol is formed from 1/2 of a glucose, a 3-carbon chunk.