Development of a novel screening method for zebrafish heart mutants. A visualized experiment.

A visualized experiment by Johannes Zipperle. Camera by Georg Kasebacher. All experiments conducted by Johannes Zipperle. Experimental design by Dr. Thorsten Schwerte. Music by Vector & Valerian.


References

(1) Chen et al.: Mutations affecting the cardiovascular system and other internal organs in zebrafish. Development 123, 293-302 (1996)

(2)Solnica-Krezel L, Schier AF, Driever W.Efficient recovery of ENU-induced mutations from the zebrafish germline Genetics 136(4). 1401-20 (1994)

(3) Schwerte, T., Fritsche, R. :Understanding cardiovascular physiology in zebrafish and Xenopus larvae: the use of microtechniques. Comparative Biochemistry and Physiology 135 131--145 (2003)

(4) Langheinrich U., Vacun G., Wagner T.: Zebrafish embryos express an orthologue of HERG and are sensitive toward a range of QT-prolonging drugs inducing severe arrhythmia. Toxicol Appl Pharmaco 15, 193(3), .370-382 (2003)

(5) Kopp R., Schwerte T., Pelster B.: Cardiac performance in the zebrafish breakdance mutant. J Exp Biol. 208(11):2123-34. (2005)

(6) Schwerte, T., Prem, C., Mairösl, A. and Pelster B.: Development of the sympatho-vagal balance in the cardiovascular system in zebrafish (Danio rerio) characterized by power spectrum and classical signal analysis. Journal of Experimental Biology 209, 1093-1100 (2006)

Category:

Science & Technology

Tags:

• zebrafish
• ENU
• screening
• development
• breakdance
• mutant
• visualized
• experiment
• danio
• rerio
• Johannes
• Zipperle
• George
• Caspa
• Vector
• and
• Valerian
• mutagenesis
• digital
• motion
• analysis
• Vector&Valerian