First Targeted Knockout Rats Using Zinc Finger Nuclease Technology

Scientists from The Medical College of Wisconsin in Milwaukee, Sangamo Biosciences, Inc., Sigma-Aldrich Corporation, Open Monoclonal Technology, Inc. and INSERM today announced the creation of the first genetically modified mammals developed using zinc finger nuclease (ZFN) technology.

In a paper published in the July 24, 2009 issue of Science, researchers describe the novel application of ZFNs to generate rats with permanent, heritable gene mutations, paving the way for the development of novel genetically modified animal models of human disease. ZFN technology will make the generation of such animals faster and will create new opportunities in species other than mice.

Category:

Science & Technology

Tags:

• knockout rats
• knockout
• zinc finger nuclease
• ZFN
• Sigma Aldrich
• genetically modified
• mice
• genes
• gene mutations
• heritable

[revolutionary17]

you know what happens to people who play god?

[elwalvador]

Sangamo (SGMO): A short-term catalyst is coming up at CROI (Conference on Retroviruses and Opportunistic Infections), where sometime between Feb 27 - Mar 2, 2011, Sangamo will present the results from two (2) Phase 1 clinical trials on their HIV therapeutic.

Sangamo Biosciences created and developed the zinc finger technology and owns all the human therapeutic rights. They license out the technology to Sigma. Don't wait you don't want to be a "day late and a dollar short" call your broker now!

[dalekdead]

they have to do these tests on humans NOT animals

[harvurd]

This sure is strange. I'd like to learn more about this. Wikipedia, here I come.

[Geronrocks1]

All Hail Fncydansir!