Topoisomerase 1 and 2
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@halr99 After cutting the strand(s) it rejoins them.
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@BigD71889 Topoisomerases relax supercoiling that has accumulated in DNA due to polymerization. Polymerase causes supercoiling since it is fixed and cannot rotate. Topoisomerases relieve supercoiling by either cutting one strand (Topo I) or both strands (Topo II)
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so topoisomerases causes chromosomal rotation? please someone answer back. Thanks
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@Moe11032 i think Helicase comes first.
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@ Moe11032: As helicase unwinds the DNA at the replication forks, the DNA ahead of it becomes overwound and positive supercoils form. DNA gyrase inserts negative supercoils by nicking both strands of DNA, passing the DNA strands through the nick, and then resealing both strands.
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Does topoisomerase comes before helicase???? someone please answe me
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topoisomerase ii is the enzme known as DNA gyrase
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Nice video !
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are you sure this is correct? I thought Topoisomerase II (aka DNA gyrase) ADD negative supercoils to bacterial DNA in order to make it more compact
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confusion 1: prof drew it on the board - recording didn't have a wide-enough angle to see it.
confusion 2: my textbook's website decided the week before finals was a good time to do maintenance and shut the site down.
thank you for saving my MD!
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just saved me hour of reading
TheMordyS 7 months ago 26
Thank you so much! I have everything for DNA replication down, EXCEPT for these topoisomerase. I accidentally wrote topoisomerase in YouTube instead of Google, but this video made it worth while and probably saved me a lot of reading.
Again, excellent video and voice over information. You're the man! Back to my MCAT studying.
aemperformance 7 months ago 9