Lipoproteins that Circulate in the Blood Collecting Fat

High-density lipoproteins (HDL), often referred to as the "Good Cholesterol", circulates in the blood stream collecting fat and cholesterol from arteries and transporting them to the liver for removal. The movie shows how these lipoproteins (in blue and green) can gather the fat molecules (in white and brown) into small particles allowing them to flow through blood vessels.

Visit here for more information:
http://www.ks.uiuc.edu/Research/Lipoproteins/

Related article:
Amy Y. Shih, Anton Arkhipov, Peter L. Freddolino, Stephen G. Sligar, and Klaus Schulten. Assembly of lipids and proteins into lipoprotein particles. Journal of Physical Chemistry B, 111:11095-11104, 2007.

Category:

Science & Technology

Tags:

• lipoprotein
• cholesterol
• blood
• fat
• hdl

[tcbguiuc]

See related article:

Amy Y. Shih, Anton Arkhipov, Peter L. Freddolino, Stephen G. Sligar, and Klaus Schulten. Assembly of lipids and proteins into lipoprotein particles. Journal of Physical Chemistry B, 111:11095-11104, 2007.

[JKM12988]

Are the movements of your 3D models derived from actual data collected from these molecular interactions? Really quite fascinating

[tcbguiuc]

The interactions of the coarse-grained beads used in the 3D models are parameterized based on physical properties (reproduction of partitioning free energies between polar and apolar phases of chemical compounds) and as such represent realistic molecular interactions of protein and lipids in lipoprotein particles.

[reavin21]

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