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Apoptosis

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Uploaded by on Aug 26, 2009

This animation explores Fas signal transduction pathway that induces apoptosis. The animation was published in the journal Science (Molecular Animation of Cell Death Mediated by the Fas Pathway, Sci. STKE 2007 (380).

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  • I've noticed that there are a few comments here about not understanding what's going on.

    Here's the Sparknote's version. Basically it is a cascade of proteins activating other proteins. Eventually, the end product protein breaks down the cytoskeleton of the cell, which determines the cell's rigidity and structure, causing the cell to essentially disintegrate.

  • I'm studying apoptosis at the moment in my course and having to write at the mo about cascade 8 so this is helpful to visualise things, I love this type of visual aid. Love the animation many thanks.

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All Comments (42)

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  • A crossbreed of "Begotten", "Dawn of the Dead" and "Toy Story".

  • think ull find this popcorn in its natural habitat

  • i would love a voiceover on this one.

  • Question:  What directs the movement of these molecules? Is it all magnetism? And if so why does each molecule only bind to certain other molecules? And how does the caspase 3 cleave proteins? Magnetism?

    Generally, how is the complex swimming, walking, binding, seeking, timing, and complex sequencing in cells directed on a molecular level?

  • Gave me a major horror film vibe. Awesome stuff.

  • This video needs more views.

  • OK, two cells walk into a bar...

  • Great! Thanks for making.

  • a conspiracy of events has to occur in order for the cell to die. beautiful

  • This is one of the greatest biology animations I have ever seen. The sound effects and high activity level make it even more appealing. Thanks!

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