Naphyrone - NRG-1 - Chemistry Behind The Headlines 2

Naphyrone, otherwise known as NRG-1, or Energy-1 has been suggested as a designer 'legal high' replacement for the cathinone drug, mephedrone.

This video explores the chemistry of naphyrone - I have significant worries about this drug, and the organic chemistry behind these concerns is explained in detail.

Music by Marillion (Happiness is the Road).

Category:

Science & Technology

Tags:

• naphyrone
• NRG-1
• mephedrone
• drug
• legal high

[Scimitar116]

Even if ALL 50mg were somewhat miraculously metabolized into the dreaded epoxides, which is extremely unlikely, wouldn't we still be getting more carcinogenic chemicals from a single cigarette? Surely, someone who smokes a pack of ciggies a day ingests *FAR* more carcinogens then someone taking even 100mg of Naphyrone daily, right?

[ProfessorDaveatYork]

@Scimitar116 You are right that the epoxidation of aromatic compounds is precisely the reason/mechanism why cigarettes are carcinogenic. It is difficult to compare the relative doses and effects, as one is inhaled (hence has primary effects on the lungs), while the other is directly ingested (and will have primary effects on the liver). In any case, people should be aware thata degree of carcinogenicity of naphyrone is a significant possibility.

[Scimitar116]

Great coverage, and while I agree that the napthalene moiety is almost certainly a not something you WANT to see, I have to make the point that there are some drugs with napthalene groups in their structures that aren't carcinogenic, i.e: the commonly available NSAID Naproxen.

Also, even if Naphyrone is carcinogenic, the effective doses are relatively small...50mg or so of the pure chemical (not the branded and cut NRG-1 product) insufflated produces nice effects, or so I've heard.

[ProfessorDaveatYork]

@Scimitar116 You are correct about Naproxen (and propranolol) containing naphthalene units. However, both those drugs have an oxygen atom directly attached to the ring, which is not present in naphyrone. The oxygen atom significantly modifies the electron density of the maphthalene ring, which will change its reactivity.

[gonzoNkc]

@logga00 You dumb. 750mg your first dose. you dont even do that shit with mephedrone.. dumb. i know using RC's is all ready dumb. but if u going to do it. do it smart.. do research. Ive done hella research and nowhere does it say suggested first dose is 750mg......everything i read says start off with 20mg. see how it effects you. most users say 50mg is ideal. dumb

[logga00]

@encabulator Mate, I completely forgot about this comment. It took me around 4 months to fully recover mentally. I was prescribed valium for about 4 months which also had bad effects and was hard to get off. This drug caused psychosis and depression. It's completely crazy. I'm really glad everything is back to normal now. I still look back on the whole experience as the worst time of my life and occasionally have flashbacks. Oh and I hear ya about the hospitals not knowing what the fuck to do.

[encabulator]

@tontonsteve I've tried loads of other party stuff over the years often in ridiculous quantities (party weekends etc) and I've never experienced anything remotely as hideous as Naphyrone/NRG-1 - go on, I dare you to use NRG-1 in a similar way to any other party substances! by the way, the rubbish which masquerades as coke these days wouldn't raise a stiffy let alone a heart rate!!

[encabulator]

@logga00 sad to say I had a similar experience - repeat/cumulative doses (like with some other party substances over a weekend as implied at 4.01) will DEFINITELY lead to a visit to the hospital with a vicious heart rate which takes ages and ages to slow down - extremely very muchly scary cos your heart feels like it's going to jump out of your chest! medics didn't have a clue what to do about it so could only watch me suffer - I suggest you only touch this stuff with a barge pole!

[tontonsteve]

@logga00

i think you sell cocaine, and this stuff will kill your business. lol

[scotthopkins94]

Not addictive in my experience with it, but very potent. 50 milligrams is enough for ten hours. A legit site to check out is naphyronenow, you can even use this promo code that i used freeuspsship5. not trying to advertise or anything but many sites offer fake substances. stay safe, stay up.

[JustARandomUsername9]

R.A.T.



[jimmyshitbags]

i fucking hate the tabloids. i wish terrorists would bomb the sun headquarters instead of aeroplanes or trains.

[logga00]

Took 750mg 5 days ago. Ended up in hospital, had a heart attack and a heart rate of 180 for over 48 hours. Now I'm in a black whole of depression. I have destroyed my life. There is no way out of this. Don't ever take it. I don't know how much longer I can take this. Life is done.