G Protein Receptor

This animation describes what takes place with a G protein receptor. G Protein Coupled Receptors (GPCRs) are proteins embedded in the surface of cells. GPCRs comprise the largest superfamily of proteins in the body. More than 1,000 different GPCRs have been identified since the first receptors were cloned. These proteins receive chemical signals from outside the cell and pass the signal into the cell, so that the cell can respond to the signal. The structures of the endogenous ligands for GPCRs are exceptionally diverse. They include biogenic amines such as norephnephrine and serotonine, peptides, glycoproteins, lipids, nucleotides, ions, and proteases. The sensation of exogenous stimuli, such as light, odors, and taste, is also mediated by this class of receptors. Activation of the receptor causes an effector inside the cell to produce a second signal chemical, which eventually triggers the cell to react to the original external chemical signal. Andrea and Richard animated the signal process in this clip.
A ligand, in this case Norepinepherine (NE), binds to the receptor and induces a conformational change. This conformational change activates the a/b complex. The complex is bound to GDP while it is inactive.

GTP replaces GDP, thus activating the Alpha subunit. The activated Alpha subunit undergoes a conformational change and activates Adenylate Cyclase.

Once the Adenylate Cyclase is activated, it is then able to convert ATP. The products of ATP conversion are c-AMP and two phosphate molecules. c-AMP is a second messenger used in many processes required for cell survival and growth.

Future plans are to expand this animation to show the second messenger pathways, and further explain intracellular signaling in a variety of living processes.

Created by:

Andrea Dichele - Biomedical and Pharmaceutical Sciences StudentAndrea Dichele
Class of 2006
Pharmacy




Richard Wallace - Biomedical and Pharmaceutical Sciences StudentRichard Wallace
Class of 2006
Pharmacy




Doctor Rodgers - Biomedical and Pharmaceutical SciencesDr. Robert Rodgers
Professor of Biomedical and Pharmaceutical Sciences
Biomedical and Pharmaceutical Sciences
College of Pharmacy




Doctor Babson - Biomedical and Pharmaceutical SciencesDr. John Babson
Associate Professor of Biomedical and Pharmaceutical Sciences
College of Pharmacy

Category:

Film & Animation

Tags:

• G-Protein
• URI
• animation
• Pharmacy

[LAQueja]

EXPLAIN the fucking shit! blue block green block come on

[786pk]

mate it seems like you know what your talking about. could you just explain the process?

thank you

[Anelotes]

I think that i understood: green block is béta and alpha, bound together with GDP, then GTP comes and takes GDP's place. It provokes alpha and beta's separation. Alpha, sticked with GTP,, comes to the "blue thing" which is actualy adenylate cyclase. Hope i helped you a bit :)

[SirSirRobin]

@23Irishballer SLP... Minnesota?

[ceyrai]

Can someone please narrate while things are going on? Even subtitles would suffice. And it's too dark, it's not very visually appealing. :|

[MsMac643]

Some simple narration and a lighter-colored background would make things much better. Otherwise good work.

[cvasquez77]

Great graphics, needs some music and narration

[preeshbruh]

this video is AMAZAING if you play it right with the inception music!

[eiresm]

crap



[23Irishballer]

screw ms B. for making me watch this video!! thumbs up if you go to SLP and watched this too!!!

[imtkain]

needs epic music