Dance Your PhD 2009 - Dance of the Migrating Neuron
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Uploaded by jcshieh on Nov 13, 2008
Too many late nights in the lab?
Entry for the 2009 AAAS Science Dance Contest
http://gonzolabs.org/dance/
Title: Adhesion and Endocytosis in Neuronal Migration
Jennifer Shieh
Graduate Student
Stanford University
The dynamic dance of the nomadic neuron begins at birth.
Act I: Interkinetic Nuclear Migration
In the cerebral cortex, neural progenitors divide to give birth to more cells at the surface of the ventricle (the fluid-filled hole in the middle of your brain).
Act II: Indecision
The newborn cortical neuron migrates out to the surface of the brain, attracted and repelled by various guidance cues. These neurons pass through a multipolar stage where they may be deciding what direction to go or where to project their axon.
Act III: Directed Radial Migration
The physical movement of a neuron is much like the old PE rope-climbing exercises. A hand-over-hand extension of the leading process that must stick to a radial glial guide, followed by the thickening of part of the cytoplasm in front of the nucleus, and finally the forward movement of the cell body. For the cell body to move forward, adhesions must be weak. Endocytosis, the internalization of bits of membrane, might help weaken those adhesions, allowing the cell to let go and the cell body to move forward.
Act IV: Finding Your Fate
Once the neuron reaches its final destination, it can fulfill its fate and take its place as a fully functioning member of the brain.
Song: "Let Go" by Frou Frou
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Bizzare!
Where're the clathrin-coated pits in the dance?
XSirApocalypseX 11 months ago
as an ex-molecular/cellular bio major and current dance major, i would like to say, you are quite lovely.
flutiedootie 2 years ago
lol Bizarre but very creative. Gotta love neural migration.
Shaune1181 2 years ago
Man I wish I had a PhD
juanice 2 years ago
[Er, that's 227SI, not 221.]
itsdho 3 years ago
JEN SHIEH! You're a rockstar! I remember you tearing it up with all the neuro grad students at Dance Marathon as "Nervous Breakdown". ^_^
(This is David from your NBIO 221SI class, by the way; I'm a first-year at Brown now. =)
itsdho 3 years ago
this is my favorite entry in Dance Your PhD. I admire the thoughtful interpretation and appreciate the clear and concise explanation. Super!
carolynwk 3 years ago
kinda crowded in there...good interpetation though =P
XxXrun3sc4p3XxX 3 years ago
this is great, you are adorable
PepitoPreet 3 years ago
Nice dance. Great song choice!
dnlee5 3 years ago