Telomerase and the Consequences of Telomere Dysfunction

January 19 2010. Nobel laureate Carol Greider, Ph.D., presents the seventh annual Jeffrey M. Trent Lectureship in Cancer Research. Learn about the groundbreaking research that won her the 2009 Nobel Prize in Physiology or Medicine.

More: http://www.genome.gov/27533486

Category:

Science & Technology

Tags:

• Trent Lecture
• telomerase
• Carol Greider
• Eric Green

[god0fgod]

Can the telomerase activator drugs act as anti-ageing drugs? Seems that not much research has been done into them but also that the shortening telomeres are a reasonable factor in ageing.

[GenomeTV]

@god0fgod Researchers are actively studying telomeres impact on cell aging (and thus aging of the organism), but they need to be careful to not convert cells into cancers by altering the enzymes regulating telomere length. Cancer cells are immortal because their telomeres do not shorten during cell reproduction. Not sure we want to live forever as a giant tumor.

[wudgee]

This was very good and clear; although I was distracted by the many incorrect words in the youtube text such as 'intense titty' for intensity or 'toast' for testes etc. Congrats on the talk though and I really enjoyed it - well worth watching.

[GenomeTV]

@wudgee The words you mentioned are corrected. Thanks for your feedback.

[Matt47247523457]

Starts at 14:00

[god0fgod]

@GenomeTV Thanks for the answer.

Telomerase isn't a carcinogen though is it? So while telomerase inhibitors could be useful for cancer treatment, telomerase activators could be beneficial in the absence of cancer? Additional telomerase would only be detrimental once you have cancer if it doesn't create cancer cells to begin with? I guess further research will help us find out!

[Donal277]

"god makes teleomeres"

Yes this didnt seem out of place in a key scientific talk.

[MISTERWONKA7]

I like your style: It's more about philosophy as opposed to waving around how you identify yourself and others, unlike most people.

[xKlondikex]

@Xanajamun I'd rather hear it straight from the researchers that can answer questions as opposed to a talking head.

[xKlondikex]

@amr012atthetube Your right... Lets just stop doing science.

[amr012atthetube]

so much carnage caused to the test subjects for so little not so objective data is terrible. The nobel prize is supposed to be for peace not wontant distruction of life at its most fundamental level in the name of so called science. I would call it technical information at best that could have been achieved through oservation of naturally occuring mutations without resorting to induced mutations that may corrupt an entire species.

[Xanajamun]

This would have been more enjoyable if the presenter learned not to "a-uhm" every second syllable, gosh that was painful. If you can't speak in front of an audience dont! "...ah and so a uhm the telomeres ah so uhm are like the a-uhm so..."

[Azel247]

@johnhassle What do you mean?