Fatty acids transport

http://www.carnitinaofficialsite.it/cms/index.php?option=com_content&view...

Carnitine carries out an essential role in the transport of long chain fatty acids through the inner mitochondrial membrane. This membrane is otherwise impermeable to long chain fatty acids (≥ C12) and is only through Carnitine that they can cross the inner mitochondrial membrane in order to be beta-oxidised in the matrix.

Beta-oxidation produces acetyl groups, which when activated in the form of acetyl- CoA (acetyl coenzyme A) enter the Krebs cycle participating in energy production in the form of ATP (adenosine triphosphate).

The transport of long chain fatty acids within the mitochondria takes place with the help of three enzymes:

1. CPT I (Carnitine palmitoyltransferase I), located on the outer mitochondrial membrane, it catalyses the following reaction:

CPT I
acyl-CoA + Carnitine → acil-Carnitine + CoA

2. CT (Carnitine-acylcarnitine translocase), located on the inner mitochondrial membrane, exchanges free carnitine present in the mitochondrial matrix with acylcarnitine present in the cytoplasm and exports acetylcarnitine from the mitochondrial matrix to the cytoplasm.

3. CPT II (Carnitine palmitoyltransferase II), located on the inner mitochondrial membrane, catalyzes the following reaction:

CPT II
acil-Carnitine + CoA → acyl-CoA + Carnitine

Detoxification of potentially toxic metabolites

Category:

Science & Technology

Tags:

• Carnitine
• energy
• metabolism
• amino
• acids
• mitochondria
• mitochondrion
• fat
• burn

[jess63224]

0.01-0.03 (faTTY acids transport) love it!

[4chinonye]

i dont understand

[rossakabossakarozay]

only retards don't understand...

[MsYasminh]

very good ... but what language is this (the written information) ??

[yarrahgoffincher]

1. Acyl CoA + Carnitine -> Acyl Carnitine + CoA (catalysed by CPT I on outer mitochondrial membrane)

2.i. Exchange of free carnitine in the matrix, with acyl carnitine in the cytoplasm; ii. export of acetyl carnitine from matrix to cytoplasm (catalysed by CT - Carnitine Acyl Carnitine transferase on inner mitochondrial membrane)

3. Acyl carnitine + CoA -> Acyl CoA + Carnitine (catalysed by CPT II on the inner mitochondrial membrane)

Took me a few goes to work it out, but I got it! :)

[Cacoethes79]

This video isn't really any more explanatory that a figure in a text book.

[dipi3696]

@jess63224 hahaha the way he says it is hilarious! p.s. i created a YouTube account just to comment on your post :)