The World's First Personal Genome (Watson/Rothberg) - Part 1

Jonathan Rothberg discusses the first sequencing of an individual human genome (James D. Watson). The genome was presented in a public ceremoney at Baylor College of Medicine.

Dr. Rothberg was inspired by his son's visit to the newborn intensive care unit to develop a new way to sequence genomes on a chip. This technology "454 Sequencing" was used to sequence the first individual human genome - as discussed here - for under $1,000,000 dollars. Because the sequencing is done "on a chip" Moore's law takes over and sequencing costs are now dropping at an exponential rate. It is only a matter of time before you have your genome sequenced.

Dr. Rothberg is the father of next-generation sequencing, and inventor of 454 sequencing, as well as bead emulsion pcr (cloning by limited dilution), and clone free methods of preparing DNA libraries now in use by all major next gen genome systems.

454 Sequencing, and 454 Life Sciences under the leadership of Dr. Rothberg completed not only the first sequence of an individual human being, but also initiated the Neandertal Genome project, and uncovered the bases for the disappearance of the Honey bee (CCD) using 454 sequencing. In addition methods developed by Dr. Rothberg to span large-segments of DNA - paired end sequencing-,were recently used by scientists at 454 to understand the complexity of rearrangements present in individual genomes.

By mid 2007, 454 sequencing had enabled over 100 scientific publications.

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[bioinformaticstech]

I am actually a bioinformatics tech that works with NGS data. Interesting presentation Dr. I think we are in the process of purchasing a 454 machine.

[chalcedonym2012]

Imblack and I know now trying to find a way to make biologial weapons to get rid of my people we will be paying close attention(the bible says inventors of evil things)

[madameboval4all]

Sirry, I've been trying to post some stuff but gets stuck. Will try later.

[stewiegriffin81]

Madameboval4all,

The studies you quote have nothing to do with genome sequencing. Svirezhev and Logofet 1980 is a paper on a mathematical model on population dynamics, and Yablakov 1986 doesn't seem to be indexed on medline. In any case, I'd still like to see any supposed papers on human genome sequencing or human stem cell biology from the 1980s that are supposedly more advanced than the research being done now (as Goon5000bc claims).

[madameboval4all]

Sorry for the spam. Don't know how it works. Maybe you are researching into something different.

Best of luck.

[madameboval4all]

Actual phylogenetic similarity seems to result from such mathematical applications. In respect of ecological systems in stable equilibrium and population genetics (including genome mapping studies) Russian researchers have made far reaching advances, for which, respectively for which excellent reviews can be found in (Svirezhev and Logopet, 1980; Yablakov, 1986).[Excerpt of my paper]

[stewiegriffin81]

Goonk5000bc,

Your statements sound distinctly untrue. Kindly quote some of these supposed Soviet research papers published in the 1980's.

[goonk5000bc]

"popped" instead of "pop".Typo.

[goonk5000bc]

Highly comprehensive Genome mapping studies were completed by Soviet Union in 1982 . After the Soviet break up fleeing soviets sold the studies world wide. Since I had written a research paper in 1995 when I saw Bush shelling out billions my eyes pop out. Pilferage at it's worst. Similarly stem cell research was completed by Soviet Union around 1982. Now Americans are talking about Stem cell research which work Soviet Union completed in in early 80's. THIS IS A SCAM.