Nuclear Hormone Receptor: RXR and PPAR Bound to DNA

When nuclear hormone receptors at the cellular surface capture chemical ligands in environment, the receptors move to nucleus and regulate gene expression by binding to DNA. In this movie, peroxisome proliferator-activated receptor (PPAR-gamma) bound to a drug, rosliglitazone, forms a heterodimer with retinoid X receptor (RXR-alpha) bound to 9-cis-retinoic acid together with two fragments of coactivator (NCOA2). DNA-binding domains of the two proteins with two zinc-binding sites bind to the consensus DNA sequence AGGTCA (3DZY.pdb; Ref. Chandra et al. Nature, v456, p350).

Category:

Science & Technology

Tags:

• gene
• music
• video
• nuclear
• hormone
• receptor
• protein
• DNA
• Munakata
• Nobuo
• MaxMSP
• Jitter

[donxcore]

music is fuxing annoying af!

[iwanaha90]

wtf? sorry but i dont undestend nothing! (the music is nice)

[brazpeti]

PPARs and RXRs show nuclear localization even without ligands.

[maciejwrotek]

how the hell ppl know these things.