新的選 胚胎科技

新型的胚胎科技

Soluble HLA-G is an independent factor for the prediction of pregnancy outcome after ART: a German multi-centre study

V. Rebmann1,*, M. Switala1, I. Eue2 and H. Grosse-Wilde3
1 Institut für Transfusionsmedizin, Universitätsklinikum Essen, Virchowstrasse 179, 45147 Essen, Germany 2 Kinderwunschzentrum Berlin, Berlin, Germany 3 Institut für Immunologie, Universitätsklinikum Essen, Essen, Germany

* Correspondence address. Tel: +49-201-723-4206; Fax: +49-201-723-5906; E-mail: vera.rebmann@uk-essen.de

BACKGROUND: Soluble HLA-G (sHLA-G) has been suggested as a non-invasive marker for embryo selection to improve pregnancy rates after assisted reproduction technique (ART). Our study aimed at the identification of parameters influencing the detection of sHLA-G in embryo cultures (ECs) and at the prognostic relevance of sHLA-G in a multi-centre study.

METHODS: In total 4212 EC from 2364 cycles were randomly collected from 29 German ART centres and analysed for sHLA-G by Luminex®-based technology.


CONCLUSIONS: This study provides significant evidence that the morphological scoring system is still the best strategy for the selection of embryos but that sHLA-G might be considered as a second parameter if a choice has to be made between embryos of morphologically equal quality.

Key words: pregnancy/immunology/assisted reproduction/IVF/ICSI outcome/sHLA-G

Category:

Comedy

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• 新型的胚胎科技