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Suboxone Talk Zone: Tolerance and Dependence

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Uploaded by on Dec 28, 2008

Jeffrey T Junig MD PhD from Suboxone Talk Zone discusses the mechanism of tolerance and dependence, features of addiction to pain medication.

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  • what if any "pain" medications will work while on suboxone? my reason askingis due to a situation happened where my "friend" was in an emergengy room. He is under the suboxone treatment and was given ample amounts of medications to try and stop the pain, all narcotics....the attending doctor knew about his suboxone in his system and still proceeded to administer fentanly-175mcg every 2 hours. which my friend claimed he felt nothing in the terms of pain reduction. Is this a possiblity?

  • It depends on the amount of Suboxone your friend takes and on the type of narcotic-- there is competition at the receptor between the block from buprenorphine and the effects of fentanyl. This is one reason why it is best to try to get down to as low a daily dose of Suboxone as possible-- while taking enough to keep the addiction in remission. I find that people taking 8 mg or less of Suboxone respond to 15-30 mg of oxycodone for pain-- but they get no euphoric effect from the oxycodone.

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  • wow i appreciate everything your doing, ive been on suboxone very long and i want to get off but im so worried of relapse im in law school and cant afford that.

  • thank you for your answer. he is at 24mg of suboxone daily. will the suboxone be effective on other addictions? thank you once again!

  • Great job please keep up the great work of imformation rather than all the MisInformation that pain patients are fed.

  • This is a very good description of how this works.

    You mention that eventually the nerve cells will become more sensitive and hence fire when withdrawal is over , but can these cell become so de-sensitized that they never actually work corectly again ? Can you , in a sense, burn them out ?

    If after your initial withdrawal you fell horriable for weeks after is this any idication of "bad cells" ?

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