Control of Tumor Promotion and Metastatic Progression by Inflammatory Signaling

Air date: Wednesday, May 19, 2010, 3:00:00 PM
Time displayed is Eastern Time, Washington DC Local
Category: Wednesday Afternoon Lectures
Description: Michael Karin, PhD, will present a Wednesday Afternoon Lecture on May 19, 2010. As a distinguished professor of Pharmacology at the University of California, San Diego and an American Cancer Society Research Professor. Dr. Karin will present "Control of Tumor Promotion and Metastatic Progression by Inflammatory Signaling."

He is a leading authority on signal transduction pathways that regulate gene expression in response to extracellular stimuli, infection, inflammation and stress. Key achievements include the definition of cis elements that mediate gene induction by hormones, cytokines and stress, identification and characterization of the transcription factors that recognize these elements (members of the AP-1/ATF family) and the protein kinase cascades that regulate their activities, including the Jun kinases (JNK) and IkB kinases (IKK).

Much of Dr. Karin's current activity is focused on understanding the link between inflammation, cancer and metabolic disease as well as on understanding the signaling mechanisms used by receptors involved in inflammation and innate immunity. In addition to establishing molecular links between obesity, inflammation and cancer, this work has revealed new targets for cancer prevention and therapy. Dr. Karin has published over 300 scientific articles and is an inventor on over 30 different patents or pending patent applications. In addition to numerous honors, Dr Karin was ranked first worldwide by the Institute of Scientific Information (ISI) in a listing of most-cited molecular biology and genetic research papers published in prestigious journals.

The NIH Director's Wednesday Afternoon Lecture Series includes weekly scientific talks by some of the top researchers in the biomedical sciences worldwide.
Author: Dr. Michael Karin, University of California, San Diego
Runtime: 01:09:47
Permanent link: http://videocast.nih.gov/launch.asp?15902

Category:

Science & Technology

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