http://www.thewileyprotocol.com and Founder T.S. Wiley provides the basics on why it's important NOT to use static dosing for hormone replacement. The basic dose on the Wiley Protocol is within FDA-approved ranges, which is what it takes to treat someone, and without the peak on day 12 of the menstrual cycle, and the valleys, you cant re-set hormone receptor response. Without this, you don't have hormone restoration.
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