The kidneys will be affected in approximately one-third of all cases with lupus. Diagnosing and monitoring lupus-related kidney disease, called lupus nephritis, often requires an invasive kidney biopsy. Dr. Amy Kao of the Allegheny-Singer Research Institute in Pittsburgh, has conducted a study, supported by the Lupus Foundation of America, on evaluation of CD4 molecules on T-cells as a possible marker for lupus nephritis. Validating such a biomarker for this potentially life-threatening complication of lupus would eliminate or greatly reduce the need for kidney biopsies. In this video, Dr. Kao discusses her study and future steps for this line of investigation.