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Part 1 of 3 - Introduction to Zinc Finger Nuclease Technology

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Uploaded by on May 27, 2010

To register for future webinars, visit http://bit.ly/ZFN_Web1
For more information on CompZr Zinc Finger Nucleases visit http://bit.ly/compoZr_YouTube

It's a revolution in genomic science. A technique capable of altering the face of basic research and drug discovery. And it's here, ready to help you unlock the darkest mysteries of the scientific universe.
CompoZr® ZFN technology is a breakthrough that enables simple and efficient genomic editing exclusively from Sigma Life Science. Zinc Finger Nuclease (ZFN) technology, allows easy creation of novel cell lines and model organisms with precise and heritable gene additions, deletions or modifications.
CompoZr ZFN technology gives you the power to add, delete or swap your gene of interest. Now it's all possible.

The details:
Zinc finger nucleases (ZFNs) are a class of engineered DNA-binding proteins that enable manipulation of the genome with unprecedented ease and precision. ZFNs create targeted double-strand breaks (DSBs) in the genome at user-specified locations. These DSBs are repaired through the cell's natural DNA-repair processes, namely homologous recombination and non-homologous end joining. These DSB-caused endogenous processes are harnessed to generate precisely targeted genomic edits resulting in both cell lines and organisms with targeted gene deletions integrations, or modifications. In this webinar, we will discuss the design, mechanism of action, and various applications of ZFN technology.

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