Dead Rising 3 takes place ten years after Dead Rising 2. It follows the game's protagonist, a young mechanic named Nick Ramos as he desperately attempts to find a way out of the city of Los Perdidos before a large incendiary bomb is released to level the city.
During the events of Dead Rising 3, a nationwide pandemic of zombie outbreaks has caused human civilization to be nearly wiped out. Contained zombies are accidentally released from containment starting an outbreak in Los Perdidos. Nick and other survivors must escape the city alive before the military performs a firebombing. At some point during the initial outbreak, Nick comes in contact with a trucker named Dick, his boss Rhonda, and Annie, an infected "illegal" - a person who refuses to be chipped by the government.