SUCCESS AND FAILURES OF ALZHEIMER DRUGS

Big Pharma invested billions in drug research, drugs that target Amyloid plaque in the brain. Not one single drug has made it, all failed. The question arises whether Amyloid is the cause or the result of Alzheimer's disease. Von Grabe went after another horse instead, he targeted vascular plaque that impeded the blood flow to the brain. His ADT3 drug was highly successful and is scheduled for phases 2 and 3 clinical trials in Europe.

TAGS: ALZHEIMER'S DISEASE DEMENTIA HYPERLIPIDEMIA CHOLESTEROL JOHN HARDY, BERNT VON GRABE, X-PHARMA ADT3 PFIZER DIMEBON AMYLOIDS WTETH ELAN NEUROCHEM ELI LILLY MARK SMITH BERISLAV SLOKOVIC PLAQUE

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News & Politics

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• BERNT VON GRABE

[bvongrabe]

FORBES: British neuroscientist John Hardy says there are two key questions to ask about the failed Eli Lilly study:

1) Did the drug hit the target but still not work? If this is the case it is worrying for the whole class of drugs.

2) Did they have imaging data showing amyloid cleared?

If the amyloid is cleared in the patients who are getting the drug and the disease is getting worse, it would be a bad sign for future drugs still in testing.

[bvongrabe]

YouTube's newest strategy: Replace Tags with the name of the author. Don't they get it that tags increase distribution?

TAGS: ALZHEIMER'S DISEASE, DEMENTIA, HYPERLIPIDEMIA, CHOLESTEROL "JOHN HARDY", X-PHARMA, ADT3, PFIZER, DIMEBON, AMYLOIDS, WyETH, ELAN, NEUROCHEM, "ELI LILLY", "MARK SMITH", "BERISLAV SLOKOVIC", PLAQUE

[xmenrus]

I was in Heidelburg in 1961-1963: Patrick Henry Village, European HQ, US Army.  Lovley city: Cold beer and hot women. Couldn't get any better.

[bvongrabe]

@xmenrus haha - actually it got much better between 1965 and 1970 - after I hired a gorgious brunette (of course our relationship was purely professional) lol

[hashcook]

I think this is a pretty good brief overview of Alzheimer's drugs but I feel compelled to point out a couple of things:

1: Bapineuzumab did not show improvement but it did show effects in people with a genetic disposition to Alzheimer's disease that is quite common (APoE-4) and is undergoing further testing to see if it may be effective in these people

2: While drugs addressing amyloid are the most common pathway being examined there are other approaches, some of which are also looking good

[imjustagirl776]

Been missing you, JB. Thanks for posting this.

[SEFX3D]

Very Informative.....and eye opening... Thanks

[xmenrus]

@xmenrus Drink on empty stomach and oxygenated water flows into the blood stream quikly. I call it natures vacuum cleaner. Thoroughly cleans the blood of all known pathogens. See Dr. Robert Beck, youtube. 

[xmenrus]

@bvongrabe Very good! Back in the USA my secretary was an irish girl with 'fire engine red hair (everywhere I looked.) Also a professional relationship. I am drinking ozonated sterilized water, 4 oz a day. It oxygenates the body and destroys viruses because H2O2 is positive and it attacks cells like cancer, aids, etc. to get the extra electron to rebalance its charge. Aids, cancer, etc. cells explode. Beautifull. I found an ozonator on Ebay for $30.00. Drink on an empty