Traumatic Brain Injury and Hyperbaric Oxygen Chamber Therapy Part 3

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• For traumatic brain injury, one randomized trial provided fair evidence that HBOT might reduce mortality or the duration of coma in severely injured TBI (traumatic brain injuries) patients. However, in this trial, HBOT also increased the chance of a poor functional outcome. A second fair quality randomized trial found no difference in mortality or morbidity overall, but a significant reduction in mortality in one subgroup. Therefore, they provide insufficient evidence to determine whether the benefits of HBOT outweigh the potential harms.
• The quality of the controlled trials was fair, meaning that deficiencies in the design add to uncertainty about the validity of results.
• Due to flaws in design or small size, the observational studies of HBOT in TBI do not establish a clear, consistent relationship between physiologic changes after HBOT sessions and measures of clinical improvement.
• The evidence for use of HBOT in other types of brain injury is inconclusive. No good- or fair-quality studies were found.

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