The Mitochondria are a component of the cell called an 'organelle'. This organelle is the site for the production of something called ATP. ATP is involved in the production of raw energy. Many patients with chronic fatigue syndrome or myalgic encephalomyelitis have problems with this raw energy production cycle and suffer from sudden and drastic loss of energy and movement. For more info please see the video.
www.freedomfromme.co.uk
Probably mostly applies to viral ME, not OP ME, stenosis FM, dietary excitotoxin FM, borrelial ME?, and any of a host of other pathogenics (although the fact that many of these have similar mechanisms causing excitotoxic damage and hyperalgesia makes sense; OPs cause diastolic cardiomyopathy and excitotoxic damage, dietary excitotoxins cause direct excitotoxicity, stenosis causes ischemia in the same parts of the brain lacking bloodflow in brain imaging studies in viral ME, etc.)
synapse131 1 year ago
In fact, I am of the opinion that the "bonk"-like, reactive metabolic state is what leads to most of the excitotoxic damage that causes hyperalgesia and the micro-seizure (resulting in alpha/delta wave anomaly and all cognitive symptoms.) It's mostly the drop out in blood pressure during this "bonk" state that causes the CNS ischemia that leads to the brain problems. It all starts with the viral cardiomyopathy and vasculitis and progresses when we overdo the exercise after getting ill.
synapse131 1 year ago
This, combined with the micro-circulatory is why our muscles stiffen abnormally with even the lightest activity (even w/ Olympic level endurance athletes) but we still retain short term anaerobic strength that allows up to push past our limits. When those metabolic byproducts are not able to be recycled and cannot be removed from muscle, the result is "lockjaw light." They are correct about the raggedy fatigue being a type of "bonk"; it occurs cyclically and reactive to activity.
synapse131 1 year ago
Great video very informative and so easy to understand with the visual aids. Thanks
jibsoz 1 year ago