POWDER, created by Jeff Lait, is what I'd call an "accessible" roguelike. In fact, just to make this point, I'm going to print here all the platforms it can be played on right now: Windows, Linux, Mac OSX, Windows CE, Gameboy Advance, Nintendo DS, Playstation Portable, PS3, Wii, GP2X, and iPhone. That's a lot of different ways to play it! But, as you'll see in the video, the game is totally built with this in mind.
As far as the gameplay itself goes, this seems to be pretty Nethack-oriented but simpler as far as what you can do and what you should do. No idea how gods work, but I'm sure it'll be super-duper important, just like figuring out everything else in this game. So let's get to it!