Fourier Transform Ion Cyclotron Resonance Mass Spectrometry

FTICR-MS: Fourier transform ion cyclotron resonance mass spectrometry. An MS configuration that detects signals on metal plates from electrical currents produced by ion oscillations. The hallmark of FT-MS is its high resolution; 1-2 ppm mass accuracy or lower can be achieved. A drawback is the long cycle time required for acquisition of MS and particularly MS/MS spectra. Fourier transform analysis consists of determining the ion cyclotron resonances (which refers to the number of orbits completed/sec), not by scanning slowly through the spectrum as a function of frequency, but by recording the oscillating charge induced in a detector plate by orbiting ions as they approach and recede from that plate. FT of that time-domain data then yields ALL of the cyclotron frequencies at once, for a time saving by a factor of ~10,000. The FTICR-MS consists of an ion source, some ion optics to transfer the ions into the magnetic field, and the Ion Cyclotron Resonance (ICR) cell or Penning trap. After ion's are trapped in the ICR cell, they are excited by a resonant excitation pulse into a coherent orbit. The excitation amplifier is then turned off and the ions continue to orbit at their final radius. Ions moving near electrodes cause an image charge to form on these electrodes to balance the ions' electric field. In the case of a circular orbit, this image charge will oscillate at the ion's resonant frequency, and can be detected by a sensitive preamplifier circuit, digitized, and stored in computer memory. http://www.cprmap.com/proteomic_technologies/mass_spectrometry/1271.html

Category:

Science & Technology

Tags:

• Fourier
• transform
• ion
• cyclotron
• resonance
• mass
• spectrometry

[guest1754]

im 12 and what is this

[dkw62]

No it did not split the molecule being analyzed into its base elements. it excited the molecules present such that they could be detected. What you see separating in the video are different molecules present in the ICR cell. These molecules have different frequencies, which are related to their inherent m/z.

[aravindsn]

Can anyone tell me which software/language is used to create these kinda animation, im looking for similar application

[vermeergirl]

Looking at the size of that helix in the background, this brings a new meaning to the idea of nano-ESI-FTICR

[DarkTrunksGeorgeSim]

I don't know if it's a good idea to trust someone who goes by the name of "Pseudo1ntellectual".

=)

[hackie77]

thats too high for apes ... ^^

[optislayer9]

@PartyWithChumpsky your ego fuels your own stupidity, unless of cource you are being verbally ironic.

[smartpartzzkidd]

so the heavier particles move slower and one can separate each particle based on the frequency that each of them oscillate in the collector thingy?

[Xaselm]

@dkw62 My momma makes spaghetti in the morning My momma makes spaghetti in tonight Oh please don't forget my large meatballs The meatballs, the meatballs, the meatballs The meatballs, the meatballs, the meatballs The meatballs, the meatballs, the meatballs The meatballs, the meatballs, the meatballs

[Subspace4d]

Aha so that is how you find out what particle you have :o)

It is better than wien filter.

[paulabonitinhabh]

good for you.