The Molecular Basis of Alzheimer's Disease - Prof. Patrick C. Fraering

This movie describes the development of Alzheimer's disease at a molecular level. It shows the very important role of the amyloid-beta peptides in the generation of deadly plaques in the brain. It is proposed by the research of professor Patrick C. Fraering who is head of the laboratory of Molecular and Cellular Biology of Alzheimer's Disease at the Life Science department and Brain Mind Institute of the Swiss Federal Institute of Technology in Lausanne - EPFL.

Professor Patrick Fraering's lab website is at:
http://fraering-lab.epfl.ch/

The graphics and sound engineering is done by the Visualbiotech team with help of its rendering and simulation system called BioInspire.

Visualbiotech engineers:
Pablo de Heras Ciechomski
Robin Mange

website:
http://www.visualbiotech.ch

Music is composed by Kevin Macleod:
http://incompetech.com/

We hope you learned something new!

Category:

Science & Technology

Tags:

• Alzheimer
• Alzheimer's
• disease
• Fraering
• EPFL
• Lausanne
• Switzerland
• Patrick
• molecular
• Visualbiotech
• Swiss
• federal
• institute
• of
• Technology
• visualization
• neurons
• amyloid
• 3d
• protein
• oligomers
• dendrites
• soma
• excitation
• impulses
• vesicle
• enzyme
• secretase
• gamma
• neuronal
• brain
• cortex
• hippocampus

[BCCWritingClass]

Thank you for a helpful video. Are you saying that the fragments aggregate and form plaques first, and the plaques cause a reaction that disrupt the tau proteins which in damages microtubules as a result?

Alos, I saw an article not too long ago that said a recent study indicated that plaques may not cause damage, because dementia is seen in rats BEFORE the fragments aggregate. Is this possibly true? Thank you.

[visualbiotech]

@BCCWritingClass This video shows one hypothesis of how Alzheimer develops. It is never the last word on the subject as the understanding about the subject constantly evolves. If you tell me the paper I can possibly forward it to someone that might know.

[Joe22c]

0:29

Minor nitpick; neuronal communication across synapses is chemically based.

Communication within a neuron (ie. from axon hillock to axon terminal) is electrically based.

:)

[visualbiotech]

You're right just that we had this in mind. We also show the chemical exchange at 1:25.

There is of course electrical intra-neuron communication and chemical inter-neuron communication.

[sleekat71]

Thanks so much for this video. If we do not closely identify and describe this disease, or any other affliction for that matter, then we will not be able to know it, and if we do not know it, we will not be able to defeat it. Knowing is half the battle. My father has this happening right now, in the latter stages, and it is devastating. Videos like this give our families who suffer through this hope for the future.....Thanks.

[visualbiotech]

Thanks for encouragement. I hope that someone will find a cure some day.

[verymetal86]

well explained also..

[V2PRC]

@visualbiotech, What software do you use to make these awesome animations?

[Sicologikal]

This is a great video...bursting with up-to-date knowledge of AD. The graphics were top-class also..well done!

[sleekat71]

@GARRYKINGLIVE Thank you much sir, and I'll do my part to get people to fund the research of this disease in any shape, form, or fashion that we can. And I know there are people out there everyday and every minute working on it, and to me, that is amazing and inspiring.....hopeful as well.

[CoasterCloud]

Where is there new information about the new Amyloid-plaque-halting medicine/procedure that was discovered around 2007?