AMP Deaminase and the Purine Nucleotide Cycle in HD.mp4

The purine nucleotide cycle involves conversion of aspartate to fumarate, a key TCA cycle intermediate. During exercise, muscles utilize the purine nucleotide cycle to upregulate TCA intermediates.

AMP deaminase is key in generating IMP via a deamination reaction. IMP is necessary for subsequent reconversion to AMP via an addition of aspartate to form adenylosuccinate. Loss of fumarate from adenylosuccinate both restores AMP and is the step at which purines can be used to generate TCA intermediates for muscle.

A congenital deficiency in this enzyme can yield cramping and fatigue during demanding physical activity.

Category:

Science & Technology

Tags:

• The purine nucleotide cycle
• purine metabolism
• TCA cycle
• citric acid cycle
• GTP hydrolysis
• AMP deaminase
• AMP deaminase deficiency
• muscle cramping
• muscle fatigue
• IMP
• Adenylosuccinate
• Fumarate
• Chris Leggett
• WFU School of Medicine
• Purine Nucleotide Cycle Movie
• movie