The story of Sitamgar revolves around three central characters: Zoya, Zohaib and Zaar. Zohaib works for a multi-national company and loves Zaar. Zoya is the headstrong daughter of the company's owner. Zohaib is sent to Dubai on an assignment, where he meets Zoya. She starts to develop feelings for him but when she expresses her love to Zohaib, he puts it down to infatuation. Heartbroken, Zoya falls very sick. When she gets her tests done she finds out that she is in the terminal stages of brain tumour and has very little time left to live. She tells Zohaib that it is her last wish to be married to him. Will Zohaib sacrifice his love for Zaar and his happiness to honour Zoya's dying wish?