Neuronal Precursors, chain migration of

Neuronal precursors born in the subventricular zone (SVZ) of the neonatal and adult rodent brain migrate 3--8 mm from the walls of the lateral ventricle into the olfactory bulb. This tangentially oriented migration occurs without the guidance of radial glia or axonal processes. The cells move closely associated, forming elongated aggregates called chains, which are ensheathed by astrocytes. We have developed a culture system in which postnatal mouse SVZ neuronal precursors assemble into chains with ultrastructural and immunocytochemical characteristics equivalent to those in vivo but without the astrocytic sheath. Time-lapse videomicrography revealed that individual cells migrate along the chains very rapidly (~122 µm/hr) in both directions. Periods of cell body translocation were interspersed with stationary periods. This saltatory behavior was similar to radial glia--guided migration but ~4 times faster. Neuronal precursors isolated from embryonic cortical ventricular zone or cerebellar external granule layer did not form chains under these conditions, suggesting that chain migration is characteristic of SVZ precursors. This study directly demonstrates that SVZ neuronal precursors migrate along each other without the assistance of astrocytes or other cell types.

Category:

Science & Technology

Tags:

• Neuronal
• Precursors
• subventricular
• zone
• lateral
• ventricle
• radial
• glia
• axonal
• processes

[Choice777]

@ConstantC4 what ? can you say some more about this ? what kind of nerves..generated where, by who ? 

[norikofh]

I wonder how you identified these cells were the neuronal precursors. is there any characteristics which we can find from this movie?

[Wildwolftomboy]

Are neuronal precursor cells just embryonic stem cells? Have they just differentiated to a sort of 'no going back' point meaning they definitely will become neurones and nothing else but are not neurones yet? Or is it just because of their location in the sub-ventricular zone that means they will become neurones and nothing else? Thanks:)

[ConstantC4]

So why does the olfactory bulb need a constant supply of nerves?

[nakashu2]

dis is amazing~~~~

[MimzyMingiSakura19]

Dang!!! And Sweet!!! so that's how my neuron move