There are several known causes of mesothelioma, minimally including exposure to a mineral called Zeolite and exposure to thorium dioxide, which was formerly used in X-rays: The most common cause of mesothelioma by far, however, is exposure to the mineral asbestos, which occurs naturally but was also widely used in various industrial processes for decades.
http://www.asbestos.net/mesothelioma/causes-of-mesothelioma.html
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