The largest of the internal membranes is called the endoplasmic reticulum (ER). The term endoplasmic means "within the cytoplasm," and the term reticulum is Latin for "a little net." Like the plasma membrane, the ERis composed of a lipid bilayer embedded with proteins. It weaves in sheets through the interior of the cell, creating a series of channels between its folds. Of the many compartments in eukaryotic cells, the two largest are the inner region of the ER, called the cisternal space, and the region exterior to it, the cytosol.
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