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Ronald Perelman gives extensively to charity - he is consistently one of the world's top philanthropists, and has donated well over $200 million to charitable causes since 2002 alone.

Recently, one of his biggest transformational gifts—a $50 million donation—was to the New York Presbyterian Hospital and Weill Cornell Medical Center. The $50 million gift created the Ronald O. Perelman Heart Institute, and provided vital financial aid to the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine. On May 4, 2008, on The O'Reilly Factor, the most-watched cable news program in America, FOX News star Bill O'Reilly named Mr. Perelman an "American Patriot" for this gift during the program's "Pinheads and Patriots" segment.

In 2008, the Chronicle of Philanthropy listed Perelman as the 26th largest donor in the USA. Mr. Perelman donated $63.5 million in 2008 to causes including, but not limited to: Weill Medical College of Cornell University. Other key beneficiaries: Stand Up to Cancer, World Trade Center Memorial Fund and Ford's Theatre. Mr. Perelman pledged $25-million to Weill Medical College, in New York, to support research, education, and patient care at the Ronald O. Perelman and Claudia Cohen Center for Reproductive Medicine. In addition, Mr. Perelman pledged $15-million to Stand Up to Cancer, a Pasadena, Calif., organization that supports cancer research and efforts to advance treatment for cancer patients; $5-million to the World Trade Center Memorial Fund, in New York; and $2.5-million to Ford's Theatre, in Washington. Mr. Perelman declined to provide details about payments on those pledges. He also gave a total of $16-million to 581 nonprofit organizations, including Big Brothers Big Sisters, in Philadelphia; the Michael J. Fox Foundation for Parkinson's Research, in New York; the National Association for the Advancement of Colored People, in Baltimore; the Rainforest Foundation U.S., in New York; and other arts, education, Jewish, medical research, and women's-health groups.

In 2006 alone, he donated over $60 million to various charitable groups and causes including Carnegie Hall and the World Trade Center Memorial. Other notable donations include $20 million to the University of Pennsylvania for naming rights to the quadrangle, $10 million to New York University to create the Ronald O. Perelman Department of Dermatology, $4.7 million to Princeton University to create the Ronald Perelman Institute for Jewish Studies, and $20 million to the Guggenheim Museum.

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