FSA is a probabilistic multiple sequence alignment algorithm which uses a "distance-based" approach to aligning homologous protein, RNA or DNA sequences. Much as distance-based phylogenetic reconstruction methods like Neighbor-Joining build a phylogeny using only pairwise divergence estimates, FSA builds a multiple alignment using only pairwise estimations of homology. This is made possible by the sequence annealing technique for constructing a multiple alignment from pairwise comparisons, developed by Ariel Schwartz in "Posterior Decoding Methods for Optimization and Control of Multiple Alignments." http://www.eecs.berkeley.edu/Pubs/TechRpts/2007/EECS-2007-39.html
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imegatrone 1 month ago
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bundawartini 1 month ago
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Ondelendo 1 month ago
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bebeheuy 1 month ago
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AntoMelta 1 month ago
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willamricard 1 month ago
Looks cool.
G,C,T,A is known, but what is the >9?
Phonolith303 1 year ago