Apoptosis & Caspase 8 - PMAP

http://www.proteolysis.org
Caspase 8 is member of the cysteine-aspartic acid protease (caspase) family. The NH2-terminal region of caspase-8 contains two death effector domains (DEDs), through which it binds the DED of Fas-associated death domain (FADD). The COOH-terminal region of caspase-8 is related to the interleukin-1beta converting enzyme (ICE) family of proteases. FADD mediates the recruitment of caspase-8 to tumor necrosis factor receptor 1 (TNF-R1), where caspase-8 becomes activated, presumably by self-cleavage, and in turn initiates a proteolytic cascade that ultimately leads to apoptosis.

Two important examples of the direct initiation of apoptotic mechanisms in mammals include the TNF-induced (tumour necrosis factor) model and the Fas-Fas ligand-mediated model, both involving receptors of the TNF receptor (TNFR) family coupled to extrinsic signals. TNF is a cytokine produced mainly by activated macrophages, and is the major extrinsic mediator of apoptosis. Most cells in the human body have two receptors for TNF: TNF-R1 and TNF-R2. The binding of TNF to TNF-R1 has been shown to initiate the pathway that leads to caspase activation via the intermediate membrane proteins TNF receptor-associated death domain (TRADD) and Fas-associated death domain protein (FADD).
Design & production: Kosi Gramatikoff, PhD; client: John C. Reed, Md PhD

Category:

Science & Technology

Tags:

• Apoptosis
• caspase
• receptor
• trail
• tnf
• PMAP
• protease
• Fas
• death
• macrophage
• cytokine

[risenflame]

a little slower would be helpful.

[paulioyeuh]

@MyHonestyMightHurt i didnt know someone could be so lame :p

[ansamzedan]

thank you :) if u have a video with more details specially about TRAIL...my seminar incolves this apoptotic pathway in cancer

[MyHonestyMightHurt]

I didnt know pacman was involved :p