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Functional thyroid disorders are very common and generally overlooked in today's healthcare model. Most patients that have functional thyroid imbalances do not have primary thyroid imbalances. Thyroid metabolism is very sensitive to slight alterations in metabolism. Thyroid hormone synthesis is altered by luteal phase function, progesterone, and autoimmunity, etc. Thyroid hormone binding is influenced by essential fatty acid metabolism, testosterone, estrogen, etc. Thyroid hormone peripheral conversion is dependent on proper 5'diodinase activity and can be altered by cortisol, estrogen, hepatic dysfunction, dysbiosis, etc. Thyroid hormone receptor binding and response may be altered by inflammation, vitamin A status, and essential fatty acid levels, etc. In this section of the notes we will briefly review thyroid hormone physiology, laboratory markers for thyroid evaluation, nutrients to support the thyroid, exogenous thyroid hormone replacement, and drugs that alter thyroid metabolism.
Thyroid Physiology Review
Once the thyroid is stimulated by Thyroid Stimulating Hormone (TSH) from the pituitary, it produces thyroxine (T4) and triiodothyronine (T3) by transporting iodine into the thyroid and by stimulating Thyroid Peroxidase Activity (TPO). TPO is involved in the formation of T4 and T3 as it catalyzes the oxidation of iodine using hydrogen peroxide. The thyroid will produce 94% of the available T4 and 7% of the available T3. As we know, T4 is inactive and T3 is an active thyroid hormone. Therefore, the majority of hormone production at the thyroid is inactive T4. Once the thyroid has produced T4, it is metabolized peripherally from the thyroid into combination T3 hormones by the enzyme 5' deiodinase, mostly at the liver. Under normal circumstances, about 40% of the available T4 is converted into T3, 20% is converted into reverse T3 (rT3), which is irreversibly inactive, and 20% is converted into T3 sulfate (T3S) and triiodothyroacetic acid (T3AC). T3S and T3AC are inactive thyroid hormones until they circulate into the gastrointestinal tract and are acted upon by intestinal sulfatase into active T3. Gastrointestinal sulfatase activity is dependent upon a healthy gut microflora.
Low Thyroid Symptoms
Fatigue
Increase in weight gain even with low-calorie diet
Morning headaches that's wear off as the day progresses
Depression
Constipation
Hypersensitivity to cold weather
Poor circulation and numbness in hands and feet
Muscle cramps while at rest
Catches colds and other viral/bacterial problems easily and has difficulty recovering
Wounds heal slowly
Excessive amount of sleep required to function properly
Chronic digestive problems (hypochlorhydria)
Itchy dry skin
Low Thyroid Signs
Dry or brittle hair
Hair falls out easily
Dry skin
Low axillary temperature (this may also be caused by any endocrine imbalance)
Edema, especially facial (myxedema)
Loss of outside portion of eyebrows
If you would like to have more information or to set up a consultation and see how we can help you (or someone you know), give us a call at 208-523-1620 to schedule an appointment to see if you are a candidate for our breakthrough procedures.
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Thyroid Physiology Part 1.movby Jhklopper4,947 views
I wish your office was here in Hawaii. After having my baby 7 mos ago I'm still weak and sick. I've been to a couple of naturopathic docs that push Armour thyroid on me without finding the true cause. You seem more helpful and organized with your treatment protocols. At this point, after seeing many docs, I am still sick and broke now. I pray to GOD for a miracle and a true cure for me. My babies need me :-(
kalkeikuu 7 months ago
Great video! Well said. I just found out that I am borderline hypo from my m.d., bow my naturopsth says that I have hypo, possibly secondary from my low functioning liver or adrenal exhaustion, plus I have bad digestion. This started after having my 4th child.
kalkeikuu 9 months ago
and what is the cost?
VickyGoss 11 months ago
are you an MD
TheMrpalid 1 year ago