Beta Oxidation and fatty acid synthesis

The breakdown of fatty acids into acetyl-CoA is called Beta oxidation. In essentially the reverse of the B-oxidation pathway fatty acids are synthesized. The process of B-oxidation is not heavily regulated. Glycerol can be converted into glyceraldehyde-3-posphate and enter the gluconeogenisis pathway.

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Education

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• Biochemistry

[TheMrCGraves]

I just wanted to point out what I think is an oversight in the tutorial. Overall, a great tutorial, but at the beginning of fatty acid synthesis, I believe that malonyl-CoA is going to undergo a decarboxylation reaction. That explains the decreased number of total carbons from 5 to 4 (not including the R group). It also explains the electrons that bond to the activated acetyl group. Once again, great tutorial, but just wanted to point out that detail.

[FortuneFavorsPrep]

@TheMrCGraves This is a great point however I was trying to give a very general overview of the process of fatty acid synthesis, you are correct that it is malonyl-Coa that is decarboxylated (loss of CO2). I want to do a video specifically about fatty acid biosynthesis I was doing this just more as a comparison showing how the two pathways compare to each other in very general terms.

[iVi07MMAD]

Thank you. You are better than my instructor. -3

[cheung3305]

@FortuneFavorsPrep According to my knowledge, I want to point out that Triacylglycerol lipase is not the ONLY regulatory enzyme for beta oxidation. Carnitine acyltransferase I is also a regulatory enzyme that facilitates the entry of fatty acyl-CoA into mitochondria where beta oxidation can only happens. When there is high blood glucose, malonyl-CoA inhibits carnitine acyltransferase I to stop beta oxidation. Please tell me if I am right or wrong. By the way, this video really helps me a lot.

[masterwizard155]

can you do a vid on citric cycle and kerbs cycle and glucogenolyse and those thing thx