By: Emmanuel Derivery, Centre National de la Reherche Scientifique (CNRS)
WASH is a newly discovered Arp2/3 activator that triggers actin polymerization on a microdomain of early endosomes. This movie describes that these microdomains are highly dynamic at the surface of enlarged endosomes. Actin pymerization by Latruculin A treatment induces fusion of these microdomains, suggeting that Actin polymerization provides the force that allows segregation of distinct WASH microdomains.
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