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Pain-sensing Nerve Cells Fire

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Uploaded on Jan 21, 2014

EMBARGOED UNTIL JAN. 23 AT NOON E.S.T.
Nerve cells in the skin of a mouse ear light up when activated. Application of capsaicin activates only pain-sensing nerve cells, in a dose-dependent fashion, while potassium chloride (KCl) activates all nerve cells present. The video shows more nerves lighting up each time during the sequential application of a low dose of capsaicin, a higher dose of capsaicin (6 sec), and then KCl (10 sec).
Credit: Yushim Kim and Xinzhong Dong (courtesy of Neuron)

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