How the adaptive and innate immune system saves your life...and gives you a parking fine. Parody of "How to Save a Life" by The Fray
Project by Stephanie Hsi and Sidd Krishnamurthy
Video:
Red shi...
How the adaptive and innate immune system saves your life...and gives you a parking fine. Parody of "How to Save a Life" by The Fray
Project by Stephanie Hsi and Sidd Krishnamurthy
Video: Red shirts - Pathogen White shirt - Macrophage (Usually) Black Shirt - T-Cell
Lyrics Step one, you step on a sharp rock You say oh well, it left such a small mark But just that little bit of rust Resulted in acquiring Tetanus
Onset of this of this infection caused macrophage activation NF-kB made IL 1, 6, TNFa you begin to wonder why fever came.
What a poor defense, I'm feeling sick Redness, swelling and tenderness And I would have cleared it by now, abated Had I been vaccinated
DC TLR 5 liked flagellin And TLR 4 was LPS stalkin' Try to slip past its defense But antigens aren't innocent
Travel down the lymph nodes in a throng B seven signals growing strong
And pray that T cells miss you Yeahhhh, pray that T cells miss you
Why's this bond so strong, CD28 Costimulated and I just can't wait To proliferate, differentiate T-cells know how to save a life
As CD8 T-cells leave this place It's finally time to make just one last choice TH1 with IFN Or TH2, IL-4 secretion?
He will do one of two things He will support the macrophage Or he'll play the B cell's game CD40L will express all the same
B cells secrete IgM and D recognizes the pathogen AID help to class switch to IgG Somatic Hypermutation Complex forms between Ab-Ag Complement flows surreptitiously Punctures the membrane with all of its might And attracts lots of phagocytes
I fell on to a knife Let's do this one more time
Secondary response, I've got a friend Plasma, antibodies, and memories Soon I will clear this disease Memory response, I do a dance Damn pathogens don't stand a chance And now I will stay up with you all night Because my final is at 9...
A parking, I'll take the fine If only I had more time
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Wasn't sure what to make of this at first, but nice surprise. The musical arrangement was first class [marketable I think]. I was hoping you would mention CD28 and B7 interactions [CD80&86] during the Tc-Bc kiss.
i have my immunology final tomorrow so i was searching for helpful videos on youtube and i found yours. not only is this helpful and funny...but you guys are reppin' ucsd! thanks for being nerds and making this! =D
Autoshare makes certain YouTube activities public on the services you choose. Select only the services you are comfortable with - like Facebook, Twitter, or Google Reader - to let your friends know what you like on YouTube. You can turn Autoshare off at any time.
I was hoping you would mention CD28 and B7 interactions [CD80&86] during the Tc-Bc kiss.
Too bad the video quality came out so poorly :(
thanks for being nerds and making this! =D