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biosights: January 23, 2012 - Septins rein in the membrane
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T cells require the septin family of GTP-binding proteins to maintain the integrity of their plasma membranes as they invade through tissues. Gilden et al. reveal that sept...
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biosights: December 26, 2011 - A Twin-Track Approach to Building Desmosomes
RockefellerUnivPress
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Desmosomes are intercellular adhesions whose adhesive core is formed by two distinct classes of cadherin molecules -- desmogleins and desmocollins. Nekrasova et al. reveal ...
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biosights: November 28, 2011 - CKIδ Decentralizes the Centrosome
RockefellerUnivPress
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When a T cell encounters a target antigen-presenting cell, the lymphocyte's centrosome relocalizes to a specialized contact between the two cells called the immunological s...
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biosights: October 31, 2011 - Cofilin severs the ties between cytokinetic nodes
RockefellerUnivPress
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Cytokinetic nodes are precursor structures that assemble into the actomyosin contractile ring that separates daughter cells in cytokinesis. Chen and Pollard describe how th...
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biosights: October 3, 2011- Moesin keeps mitotic cells in shape
RockefellerUnivPress
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The ERM protein Moesin helps mitotic cells undergo a series of dramatic shape changes by linking the actin cytoskeleton to the plasma membrane. Roubinet et al. describe how...
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biosights: September 5, 2011- Actin puts the squeeze on Weibel-Palade bodies
RockefellerUnivPress
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The actin cytoskeleton has been proposed to regulate exocytosis in many different ways. Nightingale et al. use a two-color, live-cell imaging assay to reveal two contrastin...
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biosights: August 8, 2011 - Nuclear envelope starts with a clean sheet
RockefellerUnivPress
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At the start of mitosis, the nuclear envelope and nuclear pore complexes break down and disperse into the endoplasmic reticulum and cytoplasm. Lu et al. use rapid, 3D live ...
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biosights: July 11, 2011 - Oocyte microtubules show their bias
RockefellerUnivPress
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Several mRNAs are specifically transported to the anterior and posterior regions of Drosophila oocytes by microtubule-based motor proteins, but the organization of microtub...
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biosights: June 13, 2011- Tying the Golgi Ribbon to the Centrosome
RockefellerUnivPress
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The mammalian Golgi apparatus exists as a continuous ribbon that clusters around the centrosome, but the significance of this organization is unclear. Hurtado et al. identi...
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biosights: May 16, 2011- Ouch! Single Cell Wound Repair in Drosophila Embryos
RockefellerUnivPress
60 views
Individual cells must quickly repair any disruptions to their plasma membrane. Abreu-Blanco et al. describe how early Drosophila embryos remodel their membranes and cytoske...
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