Cardinal Stritch High School is a private, Catholic, coeducational high school located in Oregon, Ohio. It is part of the Roman Catholic Diocese of Toledo.

The groundbreaking for the school was performed on September 21, 1960 by then-bishop of Toledo, Bishop George J. Rehring. The first class entered the following fall. The school is named for Samuel Cardinal Stritch, a former bishop of Toledo and eventual archbishop of Chicago.

In 2006 and 2007, the school was named to the Top 50 Catholic High Schools by the Catholic High School Honor Roll.