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Total synthesis of lysergic acid via Pd-catalysed domino cyclizations
Fenderson5555
579 views
The synthesis of lysergic acid by Shinsuke Inuki et al, which uses a neat palladium-catalysed reaction, and provides the opportunity to look at the Woodward-Hoffman rules f...
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Shulgin's syntheses of 2,5-DMA, DOB and DOEF
Fenderson5555
270 views
Successive modifications of 2,5-dimethoxyamphetamine gave a fluorinated molecule with some interesting effects. (Shulgin considered the utility of radioactive fluorine for ...
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A more modern lysergic acid synthesis
Fenderson5555
1,948 views
A synthetic scheme from 2004, which uses a Suzuki coupling, and also exploits the reactivity of the indole system. DOI: 10.1021/ol0354369
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Total synthesis of lysergic acid
Fenderson5555
4,043 views
An overview of the 1956 total synthesis of lysergic acid, the product of which is one step away from LSD. A lot of "classical" methods, and one reaction that would involve ...
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Reactions in the synthesis of ketamine
Fenderson5555
1,389 views
The synthesis of ketamine, which includes a pretty neat ring expansion rearrangement.
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Reactions in the synthesis of cocaine
Fenderson5555
2,022 views
An overview of the cocaine synthesis published by Mans and Pearson in 2004.
I've glossed over the issues of diastereo- and enantioselectivity during the ring formation, ...
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DMT from tryptophan?
Fenderson5555
1,996 views
A possible route via decarboxylation and n-methylation via carbamates
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Two syntheses of mescaline
Fenderson5555
897 views
Mescaline syntheses from 2,6-dimethoxy phenol and 3,4,5-trimethoxybenzaldehyde.
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Mechanisms and named reactions in 2C-P synthesis
Fenderson5555
1,442 views
Alexander Shulgin's synthesis of 2C-P, which contains some nice named reactions and troublesome reductions.
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Mechanisms in MDMA synthesis
Fenderson5555
7,939 views
Two alternative syntheses of MDMA
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