I'm not sure I understand what they say at the end. Oprah asks how he came to this line "I'm so hollow" when he wrote the song, and he says at one moment "it meant nothing to me really" but just before that, what does he say? I cannot understand him, he speaks really too fast!
are you sure of the lyrics?
Maybe she says
"I wish you nothing but the best for you TWO"
which would be still more pathetic ;-)