Pharmacology: Oral Meds Absorption

[TheHollyW7]

omg it all makes sense now :D

[bndorhhh]

thanks so much

[only1exists]

thanks

[5cott0888]

It doesn't mention that just about every (there are some exceptions) orally given drug is absorbed in the small intestine due to it's extremely large surface area.

[1987mrnoname]

@5cott0888 that is correct, large surface area play a more significant role to drug absorption that PH. another important role is blood supply, small intestine has not only an excellent blood supply but also blood that moves on quickly to the liver, therefore creating a large diffusion gradient for drugs to move from high to low concentration.

Excellent

[danehoy]

O-H

I-O

[AssoEFP]

@billpoo90 transdermal and subcut, wrong! for topical and intratechal, I was talking for systemic drugs, and for inhalation, theoretically you are right, in practice, most often, there is not a "pure" pulmonary delivery, and thus a loss of drug, and hepati first-pass.

[AssoEFP]

to yonon08: all drugs that are absorbed via the gastrointestinal tract undergo first-pass hepatic metabolism. There only three routes of administration that allow the drug not to undergo fist-pass metabolism: IV route, sublingual route, and pulmonary.

Vincent. Check AssoEFP channel on YouTube and efp-online org.

[billpoo90]

@AssoEFP Subcutanious (injection and implantation), inhalation, transdermal, topical application, interthecal injection...

[yonon08]

does drugs that dissolves in the stomach goes directly absorbed, or it also goes to the liver for first pass metabolism effect? anyone?

[hanupharma1]

boobs are nice

[Kasmir25]

So if you've had a gall bladder removal surgery, wouldn't that effect the way some medicines (or drugs) work?

[prasadphapale]

yes, sure any kind of organ tranplantationa or functional changes in liver, bladder, kidney will affect drug response.....

[afferencia]

@prasadphapale I think, drug molecules are absorbed via intestines into the blood and they work . am i wrong?

[prasadphapale]

@afferencia yes, but major part of drug metabolism occur in liver by live enzymes CYP450

[afferencia]

@prasadphapale thanks

[afferencia]

@prasadphapale normal cell and malignant cell are identicall,just after metoses, the killer cells recogenise the cancer cell and destroy it,it recogenise by the recepters on membran, its mean there are new receptors, which are not on the normal cell,its not possible to develope a drug molecule, which can block the recepter of cancer cell and damage it?