So basically, the first time you've got 300 - 400 - 200 in compartments from left to right in the top row, and it becomes 400 - 400 - 200. Second time however, when "new" 300 mOsm/L plasma arrives, you've again got 300 - 400 - 200, but it becomes 300 - 300 - 200?! And in my textbook it's 350 - 350 - 150. What the #%$&?!
And it's not because active pumps keep pumping; they can't pump at the same rate to keep it 400 and the osmolarity in the distal tubule has to go down if the pumps correct for the dilution caused by the efflux of water from the descending tubule. What makes this extremely complex is the time dimension that has to be considered because of the continuous flow. I don't know how fast all this happens or what events can transpire during the pause, when you stop time/flow.
I don't get it, please help. How come osmolarity of the interstitial fluid doesn't go down the first time water diffuses out of the tubule on the left, but does go down every subsequent time? That is, if active pumps create a difference of 100 mOsm/L between the interstitial fluid and the fluid in the proximal/descending tubule of the loop of Henle, and water thus diffuses from the descending tubule, shouldn’t the osmolarity be 350 mOsm/L on each side (interstitial and descending tubule)?
So basically, the first time you've got 300 - 400 - 200 in compartments from left to right in the top row, and it becomes 400 - 400 - 200. Second time however, when "new" 300 mOsm/L plasma arrives, you've again got 300 - 400 - 200, but it becomes 300 - 300 - 200?! And in my textbook it's 350 - 350 - 150. What the #%$&?!
SkymanBrother 3 weeks ago
And it's not because active pumps keep pumping; they can't pump at the same rate to keep it 400 and the osmolarity in the distal tubule has to go down if the pumps correct for the dilution caused by the efflux of water from the descending tubule. What makes this extremely complex is the time dimension that has to be considered because of the continuous flow. I don't know how fast all this happens or what events can transpire during the pause, when you stop time/flow.
SkymanBrother 3 weeks ago
I don't get it, please help. How come osmolarity of the interstitial fluid doesn't go down the first time water diffuses out of the tubule on the left, but does go down every subsequent time? That is, if active pumps create a difference of 100 mOsm/L between the interstitial fluid and the fluid in the proximal/descending tubule of the loop of Henle, and water thus diffuses from the descending tubule, shouldn’t the osmolarity be 350 mOsm/L on each side (interstitial and descending tubule)?
SkymanBrother 3 weeks ago
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SkymanBrother 3 weeks ago
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SkymanBrother 3 weeks ago
great video!
maiercc 4 months ago